Toxic epidermal necrosis - Nekrosis Epidermis Beracun
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Karakteristik mundhut kulit Nekrosis Epidermis Beracun (Toxic epidermal necrosis)
References
Stevens-Johnson Syndrome (SJS) lan Toxic Epidermal Necrolysis (TEN) minangka kahanan langka ing ngendi kulit ngalami nekrosis lan gumpalan sing akeh. Ing babagan perawatan, cyclosporine efektif banget kanggo SJS, dene kombinasi immunoglobulin intravena (IVIg) lan kortikosteroid paling apik kanggo kasus SJS lan TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Toxic epidermal necrolysis (TEN) minangka reaksi kulit serius sing disebabake dening obat-obatan tartamtu lan aktivitas sistem kekebalan, nyebabake detasemen gedhe-gedhe saka lapisan kulit njaba (epidermis) , mengaruhi luwih saka 30% permukaan awak. TEN nduweni tingkat kematian luwih saka 20%, asring amarga infeksi lan kesulitan ambegan. Mungkasi obat sing nyebabake reaksi kasebut, nyedhiyakake perawatan sing ndhukung, lan nggunakake perawatan tambahan bisa nambah asil. Panaliten anyar nuduhake yen obat-obatan kaya cyclosporine, inhibitor alpha faktor nekrosis tumor, lan kombinasi globulin imun lan kortikosteroid intravena bisa mbiyantu, adhedhasar uji coba sing dikontrol kanthi acak lan analisis saka pirang-pirang studi.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Recent Advances: There is improved understanding of pain and morbidity with regard to the type and frequency of dressing changes. More modern dressings, such as nanocrystalline, are currently favored as they may be kept in situ for longer periods. The most recent evidence on systemic agents, such as corticosteroids and cyclosporine, and novel treatments, are also discussed.
Penyebab paling umum yaiku obat-obatan tartamtu kayata lamotrigine, carbamazepine, allopurinol, antibiotik sulfonamide, lan nevirapine. Faktor risiko kalebu HIV lan lupus erythematosus sistemik. Perawatan biasane ditindakake ing rumah sakit kayata ing unit bakar utawa unit perawatan intensif.
○ Pengobatan
Iki minangka penyakit serius, mula yen lambe utawa tutuk kena utawa kulit dadi blistered, goleki dhokter sampeyan kanthi cepet.
Obat-obatan sing curiga kudu mandheg. (contone, antibiotik, obat anti-inflamasi non-steroid)